Windows registry is constantly active, with processes reading & writing entries at a mind-numbing pace. problems with the Windows Installer database have been notorious for this in the past. Bad entries in certain parts of the registry can break parts of Windows, sometimes permanently, e.g. It's not that uncommon for some software to add 20-30k new entries during installation. Google Play or win10's store, there are no rules enforced when it comes to Windows software, and that includes writing anything to the registry. Windows Registry is basically a database spread across several files storing data that's used by every facet of Windows. If an app like Wise Registry Cleaner Pro removes that entry - it seems after all to be useless - it may break that app. Then a new version of that app is released, and that file's no longer used, but the old programming code that checks the registry for that entry remains. An example of how this could cause a problem is say if an app added a required file to the hard drive, and performed a check to make sure that file's location was recorded in the registry. Some other registry entries refer to entries elsewhere in the registry, and cleaners will check those as well, making sure they exist. Many of the entries in Windows Registry list files and their location or path on the hard drive - registry cleaners generally look to see if those files are there, and if not, offer to delete that entry. Setting a Restore Point should also work, though sometimes it doesn't. Short of that, there have been good reports regarding Tweakingcom Registry Backup - free with a portable version available. The safest way to find out for yourself is to do a partition image backup, and give Wise Registry Cleaner Pro a try. Some people are adamant that the registry be left alone, while some people - too many IMHO to all be shills - report that using a registry cleaner has helped performance with their copy of Windows, sometimes quite a lot. Over the years Microsoft has generally kept silent on registry cleaners, cleaning &/or defragging the registry etc., maintaining instead that Windows should be reinstalled periodically.
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